Factors of Poor Glycemic Control and its Correlation with Albumin Creatinine Ratio Among Patients with Type 2 Diabetes Mellitus: University of Gondar Compressive Specialized Hospital Amhara Region North West Ethiopia

Abstract

Abstract Background: Poor glycemic control is a main public health problem among type2 diabetes mellitus patients and it leads to diabetic complications. In Ethiopia determination for predictors of poor glycemic control level using glycosylated hemoglobin is not studied. Therefore, this study was aimed to assess predictors of poor glycemic control and its correlation with albumin to creatinine ratio using glycosylated hemoglobin. Objective: To assess factors of poor glycemic control and its correlation with albumin to creatinine ratio among type 2 diabetes mellitus patients at University of Gondar compressive specialized Referral Hospital North west Ethiopia, 2023. Method: Institutional based cross-sectional study was conducted from 01, April - 30, May /2023. This study includes 200 type 2 diabetes mellitus patients by using systematic random sampling technique among type 2 diabetes mellitus patients who have follow up at the Hospital. To measure glycosylated hemoglobin levels, serum creatinine and blood urea nitrogen, 5 ml of Blood samples were collected in early morning. Data entry and analysis were performed using SPSS version 26. Bivariate logistic regression analysis was used. Pearson’s correlation test was done to test correlation of poor glycemic control with albumin creatinine ratio (P=0.002). Result: The prevalence of poor glycemic control was 82.5%. The predictors significantly associated with poor glycemic control at 95% CI were being female (AOR=3.74, 95% CI 1.1,12.83), age >60 years (AOR 88.1, 95% CI 6.48,1197.2), BMI>25 (AOR 7.1, 95% CI 1.37,36.7), duration of diabetes (> 5 years) (AOR 4.35, 95% CI 1.1, 16.9) and anti-diabetic medication (Insulin alone) (AOR 8.39, 95%CI 1.3,56.9). There was significant positive correlation of HbA1c with ACR with (r=0.218, P value =0.002). Conclusion: Prevalence of poor glycemic control in type2 diabetes mellitus patients found to be high. Being female, age, overweight, duration of diabetes, antidiabetic medication (insulin alone) significantly associated with poor glycemic control. HbA1c significantly correlate with albumin creatinine ratio. We recommended to those hospital health workers Effective educational and therapeutic approach should be focused controlling body weight particularly on female patients.