EVALUATION OF HEPATOPROTECTIVE EFFECT OF 80% METHANOL GINGER (ZINGIBER OFFICINALE) LEAF EXTRACT AGAINST ETHANOL-INDUCED HEPATIC TOXICITY IN SWISS ALBINO MICE

Abstract

Abstract Background: The burden of alcohol drinking is multifaceted, affecting individuals, families, communities, and society at large. The damaging consequences of excessive alcohol drinking on our health, social environment, and financial well-being becoming a public health problem which need an intervention. In that case, we can make preventive efforts to decrease this burden. Hepatotoxicity brought on by alcohol, which includes liver damage, is a major global health problem. Objective: The aim of this study was to investigate the hepatoprotective effect of Ginger leaf extract against alcohol-induced liver injury in Swiss albino mice. Method: Thirty-six male albino mice were divided into six groups (n = 6), with Group I serving as the normal control, Group II as the negative control, Groups III through V serving as the test groups (alcohol + varying doses of Ginger leaf extract [100, 200, and 400 mg/kg]), and Group VI serving as the positive control. A blood sample was collected through a cardiac puncture and used to evaluate the outcomes of biochemical parameters, and lipid profiles. Liver tissue was taken out and used to evaluate the outcomes of histological liver examinations. A one-way ANOVA was used to assess statistical significance, and then Tukey's post hoc test was used. P-value < 0.05 was considered statistically significant. Results: The results indicated that mice fed with ethanol developed elevated liver biochemical markers, dyslipidemia, and mild steatosis, which are the characteristics feature of binge alcohol induced liver disease. The affected parameters were effectively restored by hydro methanolic extract of Ginger leaf (Zingeber Officinale) and the results were statistically significant (P≤0.05). Conclusion: The study found that Ginger leaf crude extract has hepatoprotective effects against alcohol-induced liver damage in mice.