Abstract:
Abstract
Background: The burden of alcohol drinking is multifaceted, affecting individuals, families,
communities, and society at large. The damaging consequences of excessive alcohol drinking
on our health, social environment, and financial well-being becoming a public health problem
which need an intervention. In that case, we can make preventive efforts to decrease this
burden. Hepatotoxicity brought on by alcohol, which includes liver damage, is a major global
health problem.
Objective: The aim of this study was to investigate the hepatoprotective effect of Ginger leaf
extract against alcohol-induced liver injury in Swiss albino mice.
Method: Thirty-six male albino mice were divided into six groups (n = 6), with Group I serving
as the normal control, Group II as the negative control, Groups III through V serving as the
test groups (alcohol + varying doses of Ginger leaf extract [100, 200, and 400 mg/kg]), and
Group VI serving as the positive control. A blood sample was collected through a cardiac
puncture and used to evaluate the outcomes of biochemical parameters, and lipid profiles. Liver
tissue was taken out and used to evaluate the outcomes of histological liver examinations. A
one-way ANOVA was used to assess statistical significance, and then Tukey's post hoc test
was used. P-value < 0.05 was considered statistically significant.
Results: The results indicated that mice fed with ethanol developed elevated liver biochemical
markers, dyslipidemia, and mild steatosis, which are the characteristics feature of binge alcohol
induced liver disease. The affected parameters were effectively restored by hydro methanolic
extract of Ginger leaf (Zingeber Officinale) and the results were statistically significant
(P≤0.05).
Conclusion: The study found that Ginger leaf crude extract has hepatoprotective effects
against alcohol-induced liver damage in mice.
