Abstract:
Abstract
Introduction: Kidney is vulnerable to drug-induced damage because of its relatively high blood
flow from cardiac output. Cisplatin-induced kidney damage is one cause of acute kidney injury
frequent adverse event that increases morbidity and the need for health care. However there is no
any drugs used as a treatment for it. Therefore searching effective, affordable, and safe drugs for
the prevention and curative effect of kidney toxicity caused by cisplatin is mandatory.
Objective: This study aimed to evaluate the effects of Foeniculum vulgare Mill hydromethanol
crude leaf extract on cisplatin-induced nephrotoxicity in Swiss albino mice
Methods: The study was conducted on 42 male Swiss albino mice. Mice were allocated randomly
into 7 groups, 6 mice per group. Group I was received distilled water only, Group II& Group III
was treated with 7.5mg/Kg cisplatin only on the 1st &11th day respectively. Group IV-VII,
Foeniculum vulgare Mill were screened at two dose levels, i.e., 200 mg/kg bd. Wt. and 400 mg/kg
bd. Wt. in both curative and prophylactic regimens plus a single dose of 7.5 mg/kg cisplatin on 1st
& 11th day respectively. The mice were anesthetized and sacrificed on day 15 after the last
treatment followed by overnight fasting. Then kidney function tests, and histopathological
investigation were done. The data was entered into epi-data version 4.7, exported to SPSS version
25.0, and analyzed by using one-way ANOVA followed by Tukey’s post hoc test.
Results: Mice that received cisplatin alone (group II&III) exhibited a significant decrease in body
weight on day 15, increase in serum markers (creatinine, uric acid, urea), with increase relative
kidney weight, and pathological damage to the kidney as compared with normal control group.
The group of mice with curative and prophylactic regimens of 200 and 400mg/kg Foeniculum
vulgare Mill leaves extract reduced the serum kidney markers, prevent the pathological damage to
the kidney in mice as compared with its negative control groups. Curative lower dose showed
significant difference in serum uric acid level as compared with normal control group. But lower
dose of extract unable to reduce relative kidney weight as compared with negative control groups.
Conclusion: The finding of the present study brought that Foeniculum vulgare Mill exhibits
nephroprotection activities both in curative and prophylactic regimen by ameliorating
nephrotoxicity in dose dependent manner. But, slightly better in prophylactic regimen
