Abstract:
Tuberculosis (TB) caused by Mycobacterium tuberculosis (MTB) remains a major global public
health concern. Extra pulmonary TB accounts 15% of global TB burden and Ethiopia has
reported a higher than average proportion of extra pulmonary tuberculosis (EPTB). Urinary tract
TB (UTB) is one of the most common types of EPTB and is also considered as a severe form of
EPTB in clinical practice. The diagnosis of UTTB is difficult the symptoms are similar to other
bacterial infections, which serves as the major cause for delay diagnosis of UTTB patients. The
data on diagnosis of urinary tracttuberculosis byGen X-pert MTB/RIF assayfrom developing
countries including Ethiopia is yet limited due to constraints of resource and limitedaccesses
ofGeneX-pert MTB/Rifampicin. The objective of this study was tocompare Gene X-pert
MTB/RIF assay with convectional(Ziehl Nielsen and florescence microscopy) diagnosis for the
detection of urinary tract tuberculosisfrom urine specimen among mycobacterium tuberculosis
positive and suspected urinary tract tuberculosis casesat university of Gondar comprehensive
specialized hospital, North West Ethiopia.A Hospital-based cross-sectional study was conducted
among 64 sample with mycobacterium tuberculosis positive and suspected urinary tract
tuberculosisat university of Gondar comprehensive specialized hospital. Non-randomized
purposive sampling technique was used to select study participants. A urine sample was
collected and smearmicroscopyZiehl Nielsen and florescence microscopy was done. A Gene XpertReal-time PCR was conducted to check the sample, hand free processing and DNA
extraction platform. A total of 64 participants were enrolled in this study with response rate of
100%. Two third, 41 (64.1 %) were males and majority of the study participants were in the age
group of 31-45 years, from majority of study participants 46 (71.9%) were from rural residence
and 37(57.8%) were illiteratein education. Conclusion and recommendationthe prevalence of
urinary tract mycobacterium tuberculosis by Gene X-pert and florescence microscopy 3(4.7%)
and 1(1.6) which is slightly higher. The prevalence is higher in urban resident and female sex
group. Gene X-pert more specific than convectional method. Develop guideline on how to use Expert in urine sample and diagnosis for UTTB
