Abstract:
Introduction. Sepsis, defined as organ dysfunction caused by a dysregulated host response to infection, is associated with high mortality and rapidly became a significant global health burden. Sepsis and septic shock are the major causes of morbidity and mortality in Intensive care Units (ICUs) in low and middle-income countries. Stress hyperglycemia is a transient increase in blood glucose level during stressful events like sepsis and is common in critically ill patients. Several studies have demonstrated increased risk of mortality and future diabetes in these patients. There is paucity of information on this subject in sub Saharan Africa including Ethiopia.
The swiftly growing population of people living with diabetes in Ethiopia and lack of elaborated scientific data on Stress hyperglycemia among critically ill patients in Ethiopia prompted this work. This study will set out to assess the enormity and associated factors of critical illness hyperglycemia among sepsis patients admitted to MICU, UOG Referral Hospital, Gonder, Northwest Ethiopia.
Objectives: To assess the magnitude of Stress hyperglycemia and associated factors among sepsis patients admitted to MICU, from September 12, 2019 to February 15, 2025, UOG Referral Hospital, Gonder, Northwest Ethiopia.
Methods: An institution based cross-sectional study conducted at MICU of UOG Referral Hospital using structured questionnaire on 226 patients during September, 12, 2019 to February, 15, 2025. Data was collected using patient record review. Both bivariate and multivariate binary logistic regression employed to identify factors associated with hyperglycemia of critical illness. Odds ratios with their 95% CI and P value less than 0.05 was used to determine statistically significant associations.
Results. This study revealed 79 sepsis patients which it is 35% developed stress hyperglycemia. being from rural (AOR= 5.5; 95% CI (2.3-12.1), hyperglycemic range RBS on admission (AOR= 8.4; 95% CI (3.4-21),increased blood ALT level (AOR= 3.2; 95% CI (1.2-8.6), Diabetes mellitus AOR= 5.1; 95% CI (2.2-12), low GCS on admission AOR= 4.02; 95% CI (1.68-9.64) and death outcome (AOR= 2.32; 95% CI (1.01-5.35) showed statistical association with stress hyperglycemia..
Conclusion; from this study prevalence of stress hyperglycemia is 35%. place of residence, RBS on admission, blood ALT level, Diabetes mellitus, GCS on admission, and outcome were associated with stress hyperglycemia in sepsis patients admitted to MICU from September 12, 2019 to February 15, 2025
