ANALGESIC, ANTI-INFLAMMATORY AND ANTIPYRETIC ACTIVITY OF
HYDROMETHANOLIC AND ESSENTIAL OIL EXTRACT OF LAGGERA TOMENTOSA
(ASTERACEAE) LEAVES IN MICE

dc.contributor.author	DEGU, ABREHAM
dc.date.accessioned	2025-07-09T08:59:29Z
dc.date.available	2025-07-09T08:59:29Z
dc.date.issued	2025-07-09
dc.identifier.uri	http://hdl.handle.net/123456789/9609
dc.description.sponsorship	ntroduction: Laggera tomentosa (Asteraceae) is a well-known medicinal plant claimed to treat various causes of pain, inflammation, and fever. Previous in vitro study also confirmed the antioxidant activity of the plant. However, the plant's in vivo activity has not yet scientifically evaluated. Objective: To evaluate the Analgesic, Anti-inflammatory and Antipyretic Activity of 80% hydromethanolic and Essential oil extract of Laggera tomentosa (Asteraceae) leaves in Mice. Methods: Shed dried leaves of Laggera tomentosa was macerated with 80% hydro-methanolic solution. The essential oil was extracted through hydro-distillation of the leaves of Laggera tomentosa with Clevenger apparatus. After the toxicity study 100 mg/kg, 200 mg/kg and 400 mg/kg of both essential oil and crude hydromethanolic extract were used to evaluate the analgesic, anti-inflammatory and antipyretic activity. The analgesic activity was evaluated with chemical, and hot plate methods. As an acute anti-inflammatory activity of the two extracts was evaluated by using carrageenan induced paw edema model, chronic anti-inflammatory activity was tested with cotton pellet model in mice. Finally, antipyretic activity was tested with yeast-induced hyperthermia model in mice. The results were analyzed using IBM SPSS version 26.0 and statistically significant differences within and between groups were assessed by one-way Analysis of Variance followed by post hoc Tukey’s tests. Result: Both 80% hydromethanolic and essential oil leaf extract of Laggera tomentosa demonstrated a statistically significant (P<0.05) anti-nociceptive activity in chemical induced and hot plate methods in dose dependent manner. Additionally, these extracts exhibited a significant (P<0.05) antiinflammatory activity both in acute and chronic inflammatory tests. The extracts also produce significant (P<0.05) antipyretic activity after induction of pyrogenic fever in mice. Conclusion: The findings of this study proved the traditional claims of the plant and concluded the analgesic, anti‑inflammatory, and antipyretic activity of the 80% hydromethanolic and essential oil leaf extract of Laggera tomentosa. However, species variation could limit such a straightforward extrapolation of the findings of this study in humans.	en_US
dc.language.iso	en	en_US
dc.subject	: Analgesic, Anti-inflammatory, antipyretic, Laggera tomenosa,	en_US
dc.title	ANALGESIC, ANTI-INFLAMMATORY AND ANTIPYRETIC ACTIVITY OF HYDROMETHANOLIC AND ESSENTIAL OIL EXTRACT OF LAGGERA TOMENTOSA (ASTERACEAE) LEAVES IN MICE	en_US
dc.type	Thesis	en_US