DRUG RELATED HOSPITAL ADMISSIONS AND ASSOCIATED FACTORS AMONG ADULTS ADMITTED AT FELEGE HIWOT COMPREHENSIVE AND SPECIALIZED HOSPITAL (FHCSH) 2020 NORTH WEST ETHIOPIA

Abstract

Abstract Introduction: Drug related hospital admission is a hospitalization due to one of the drug related problems; which is an event involving drug therapy that actually or potentially interferes with the desired therapeutic outcome. Drug related problems are prevalent with the range of from 13% to 41.3% worldwide. Unless timely recognized and made necessary intervention, drug-related problems may eventually lead to hospital admission. Objective: This study was aimed at assessing the prevalence, and associated factors of drug related hospital admission among adult patients admitted to the medical wards of the Felege Hiwot Comprehensive Specialized Hospital (FHCSH). Method: Across-sectional study was conducted at the internal medicine wards of Felege Hiwot Comprehensive and Specialized Hospital fromJune1 to September 15, 2020. Structured questionnaires and an assessment tool for drug related hospital admission, ATHARM10 tool,

were used for data collection by two clinical pharmacists from July 1 up to September 15, 2020, prospectively. The data was entered into Epidata 4.7.2 software, then transformed to Statistical Package for Social Sciences (SPSS® (IBM Corporation)) software version 24 for analysis. Descriptive statistics were presented by using frequency and proportion. Binary logistic regression was applied to identify factors associated with drug related hospital admission with a 95% confidence level and a p-value of 0.05. Result: The prevalence of drug related hospital admissions was 31.9% (95% CI = 27.7%36.4%).

From this, non-compliance 37.8% (95% CI = 29.6 - 45.9), untreated indication 31.9% (23.7 - 40), and adverse drug reaction 15.6% (95% CI = 9.6 – 21.5), accounts the three top drug related hospital admission. About 28.8 % of all admissions, were preventable. The most of drug related hospital admissions were moderate (76.3) to severe (21.5) and preventable (80.7). Patients with lower to medium Charlson comorbidity index score, longer duration of therapy, and who did not have health insurance significantly associated with drug related hospital admissions. Conclusion and recommendation The prevalence of drug related hospital admissions was considerably high. Non-compliance and untreated indications were the commonest drug related problems that caused drug related hospital admissions. Emphasis should be given on drug therapy optimization to prevent and manage drug related problems. Key Words: drug related hospital admission, drug related problems, prevalence, associated factors, patterns, Bahir Dar, Northwest Ethiopia.