Assessment of Drug related Problems and Associated Factors Among Ca ncer Patients North West Ethiopia Hospital Based Observational, Crosssectional Study

Abstract

ABSTRACT Background: Drug related problem is an event involving drug therapy that actually or potentiall y hampers with desired health outcomes. The complex nature of cancer therapy is associated wit h drug related problems.Understanding the prevalence of drug related problem and the predictive factors among cancer patients enables early detection and appropriate management of the proble m to improve patient care. Aim: To assess the prevalence of drug related problems and associated factors among cancer patients. Method: Hospital based observational crossectional study was conducted from April 1 July 15/2021 in cancer treatment centers North west Ethiopia among cancer patients. Convinenc e sampling procedure was used to select the study participants. Data were first entered in to epida ta version 4.6 then transported to SPSS version 25 for analysis.Bivarte logistic regression analys was employed to identify determinants and variables with p values < 0.2 on bivariate logistic reg ression model was entered into a multivariable logistic regression model and variables with p val ue<0.05 were considered as statistically significant.

Result: A total of 321 cancer patients were participated in the study. Among participants the

majorty 211(65.7%) were females. A total of 615 drug related

problems were identified in

245(76.3%) patients diagnosed and treated with cancer. Among the drug related

problems identi fied, adverse drug reaction 25.37%, non adherence 22.11%, dose too high 18.9%, dose too low 1 5.6% and need additional drug therapy 13% were the most prevalent DRPs. Factors associated w ith occurrence of drug related problems included comorbidities (AOR=3.460,95%CI (1.363-8.78 4), low and medium adherants (AOR=3.915,CI(1.973-7.767) and (AOR=4.294,95%CI=1.915-9. 629) repectively,source of medication fee (AOR=2.666,95%CI (1.275-5.576) and polypharmacy

(AOR=2.048, 95%CI (1.104-3.798) .

Conclusion: The finding of this study showed that the prevalence of drug related problems in ca ncer patients were high. The presence of comorbidity, polypharmacy, adherence and source of m edication fee were independent predictors of

DRPs.

Key words:

Cancer, Chemotherapy

,

Drug related problem