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The Effect of Metoclopramide Prophylaxis for Nausea And Vomiting After Spinal Anaesthesia for Emergency Cesarean Section at the University of Gondar Hospital, Northwest Ethiopia, 2014

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dc.contributor.author Simeneh Endalew, Nigussie
dc.date.accessioned 2017-06-07T18:42:41Z
dc.date.available 2017-06-07T18:42:41Z
dc.date.issued 2014-06-01
dc.identifier.uri http://hdl.handle.net/123456789/515
dc.description.abstract Background: - Nausea and vomiting is multifactorial and common problem after spinal anaesthesia for cesarean section which can be unpleasant and disturbing to the patient and making surgery difficult. So that it is sensible to administer prophylaxis drugs with gastrokenitic and antiemetic property for emergency caesarean section. Metoclopramide is believed to be effective to reduce both the incidence and severity of intraoperative and early postoperative nausea and vomiting for cesarean section in some studies. But its effectiveness of reducing the risk of nausea and vomiting after spinal anesthesia for emergency cesarean section was undetermined in our country, Ethiopia. There may be variation in the population demographics and anaesthetic and surgical managements. Objective: - the aim of this study was to assess the effectiveness of metoclopramide prophylaxis for intraoperative and early postoperatve nausea and vomiting after emergency cesarean section under spinal anaesthesia at GUH. Methods: - prospective observational study was conducted to assess the effectiveness of metoclopramide. Patients who took 10mg metoclopramide prophylaxis were grouped as group A and without prophylaxis were grouped as group B. pretested observational checklist and interview questionnaire were used to collect the data during CS, and at the 2st , 4nd and 6th hour after cesarean section. Descriptive statistics was calculated for most variables. Student t test or Mann Whitney U tests were used when appropriate. Chi-square and Fisher exact tests were used to compare the proportion of categorical variables between the groups. Results: - The prophylaxis group with 10mg metoclopramide (n=66) compared with non prophylaxis group (n=66) resulted a significant reduction in the overall incidence of intraoperative and early postoperative nausea and vomiting (25.8% vs. 48.5%, p=0.007). The median score for nausea on a linear numeric rating scale were also reduced in the prophylaxis group [0(0-7) vs. 0 (0-9), p=0.037] at the end of CS and [0(0-6) vs. 0 (0-9), p=0.006] at 2hour and [0(0-6) vs. 0 (0-8), p=0.031] at 4hour. The frequency and number of vomiting episode was also significantly reduced in the prophylaxis group. Conclusion and recommendation: - Metoclopramide can reduce the incidence and severity of nausea and vomiting when used as prophylaxis before emergency cesarean section under spinal anesthesia. en_US
dc.description.sponsorship UOG en_US
dc.language.iso en_US en_US
dc.title The Effect of Metoclopramide Prophylaxis for Nausea And Vomiting After Spinal Anaesthesia for Emergency Cesarean Section at the University of Gondar Hospital, Northwest Ethiopia, 2014 en_US
dc.type Thesis en_US


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