DETERMINATION OF PROTHROMBIN TIME, ACTIVATED PARTIAL THROMBOPLASTIN TIME AND PLATELET COUNT OF TYPE II DIABETES MELLITUS PATIENTS ATTENDING FELEGEHIWOT REFERRAL HOSPITAL, BAHIR DAR, NORTHWEST ETHIOPIA

Abstract

Introduction: Diabetes mellitus is a metabolic disorder characterized with chronic hyperglycemia which results in polyuria, polydipsia and polyphagia. The incidence of cardiovascular disease (CVD) due to thrombosis is 2-4 folds greater in diabetic patients than the general population. Prothrombine time, activated partial thromboplastin time and platelet count are hematological indices that give an insight about the coagulation status of diabetic mellitus patients. Objective: -To compare Prothrombin time, activated partial thromboplastin time and platelet count of type II diabetes mellitus patients attending Felegehiwot referral hospital, Bahir Dar, Northwest Ethiopia. Method: A comparative cross-sectional study from March to April 2015 was carried out on a total of 40 treated type II diabetic, 40 untreated diabetics and 40 non-diabetic controls with similar age range of 30-60years.Simple random sampling technique was used to select study subjects of untreated DM and systematic sampling technique was used to select study subjects of both treated type II DM and non-diabetic individuals. Demographic data were collected through face to face interview and about 4ml of blood was collected aseptically by Felegehiwot referral hospital laboratory staff. The collected data was entered and analyzed through SPSS ver 16.One-way Anova and independent t-test were used to compare means of PT, aPTT and platelet count. P <0.05 was considered as statically significant. Result: The Mean aPTT in second was 34.44±5.35, 25.42±8.46, and 32.79±4.12; mean PT in second was14.65±2.50, 13.54±3.44, 14.28±1.50 and mean Platelet count was 254,000±95,077, 250,000±75,546, and 251,000±71,964 in treated type II diabetes mellitus, untreated and non-diabetic individuals, respectively. There was statically significant shortening of aPTT in untreated diabetes mellitus patients when compared with both treated diabetics and non-diabetic individuals (P <0.05). However there was no significant difference between treated and non-diabetic controls. There was no statistical significance difference of PT and platelet count between all groups (P >0.05). Conclusion and recommendation: There was a shortening of aPTT in untreated type II diabetic patients. Therefore, monitoring the aPTT in newly diagnosis diabetic patients is important.