Assessment of liver marker enzymes and its association with type 2 diabetes mellitus in Northwest Ethiopia

Abstract

Objective: This study aimed to assess the level of aspartate aminotransaminase (AST), alanine aminotransaminase (ALT) and gamma-glutamyltransferase (GGT), and their association with type 2 diabetes mellitus in Northwest Ethiopia. Results: Using a cross-sectional study, blood samples were collected from 192 Type 2 diabetes mellitus (T2DM) participants and 192 healthy age and sex-matched volunteers. The study was carried out from May to August 2017. The serum concentration of aspartate aminotransaminase, alanine aminotransaminase, and gamma-glutamyltransferase were measured using A25 Bio-system fully automatic chemistry analyzer and using the manufacturer’s kit of the machine. Liver function test results of T2DM participant were significantly higher than those of the control group, serum ALT (46.06±22. 38 IU/L) and serum AST (42.94±19. 08 IU/L), P < 0.001, while the level of GGT in both study groups was not significantly associated (P=0.065). In conclusion, the evaluation of liver marker enzymes showed a significant association with Type 2 diabetes participants compared with the controls. Keywords: Gamma-glutamyltransferase, Aspartate aminotransaminase, Alanine aminotransaminase