Abstract:
Many infectious diseases have been known to be treated with herbal remedies throughout the history of
mankind. A recent review indicated that more than 80% of the world’s population relied on traditional
medicine for their primary healthcare needs. Tragia (Tragia cinerea), which belongs to the family
Euphorbiaceae, is used as a medicinal plant. Therefore, the aim of the present study was is to evaluate
the antibacterial activity of the Tragia cinerea plant. The experimental study design was used to
determine the antimicrobial activity of crude extract of Tragia cinera (methanol and chloroform)
against Staphylococcus aureus, klebsiella pneumonia, Escherichia coli, and p.aeruginosa. The
antimicrobial sensitivity of the crude extract of Tragia cinerea was determined by using Muller Hinter
agar, and MIC and MBC were determined by using the nutrient broth dilution technique. Finally, the
data was recorded and interpreted by using SPSS statistical software (version-21) that was calculated
mean and standard deviation. The crude extract, methanol, and chloroform showed antibacterial
activities against all test pathogens. The most susceptible bacterium to crude extract was S. aureus with
a mean zone of inhibition 9.66±0.57bmm. Similarly, in chloroform and aqueous fraction, P.
vertiginous was more susceptible to the zone of inhibition 9mm. Furthermore, only the crude extract
and chloroform fraction revealed antibacterial activity against K. pneumonia. However, E. coli was not
susceptible to the crude extract of all solvent fractions.
