Abstract:
Antibacterial agents have saved many lives and helped the growth of modern medicine over the past half
century. The emergence of drug resistance, jeopardizing the effectiveness of these life-saving treatments. This
clearly highlights the urgent need for new and improved antibacterial drugs with a novel target and new molecular
structure agent to obviate cross-resistance. This paper reviewed the possible new ways to discover novel
antibacterial agents. The most widely studied new bacterial targets for novel drug development are quorum
sensor biosynthesis, bacterial virulence factor, bacteria cell division machinery, Bacterial cell wall synthesis, PDF
inhibitor, isoprenoid biosynthesis, shikimate synthesis pathway, biofilm synthesis and fatty acid biosynthesis.
These new discovery routes have given rise to agents that are in preclinical trials. This review also discusses the
alternatives approaches that act bacteria or any approaches that target the host. The most advanced approaches
that are on clinical development are phages and other approaches that are on preclinical development are
antimicrobial peptides. These alternatives ways may use as adjunctive therapies, which suggest that conventional
antibacterial agents are still essential.
