Abstract:
The current study was undertaken from December 2015 to May 2016 with the aim
of determining and comparing the pathogenicity and response to diminazene
aceturate (DA) and isometamidium chloride (ISM) treatment in experimentally
infected mice with trypanosome isolates from Jawi and Birsheleko areas of
northwest Ethiopia. A total of 42 mice were used for the experiment. These mice
were randomly assigned in to 7 groups of 6 mice per group. Three of the groups
(Group 1, 4 and 5) were inoculated with trypanosome isolated from Jawi and
three other groups (Group-2, 6 and 7) were inoculated with trypanosome isolated
from Birsheleko and the remaining one group (Group 3) was negative control.
Each experimental mice were received 0.3 ml of positive blood at the 105
parasites/ml from donor animals intraperitoneally while negative control group
were received 0.3 ml sterile water. The mice were clinically observed daily
during the study period. Parameters including level of parasitaemia, body weight
