Abstract:
Objective: This study was aimed to determine the prevalence of drug‑related
problems (DRPs), identify the most common drugs, and drug classes involved in DRPs as
well as associated factors with the occurrence of DRPs.
Methods: A prospective cross‑sectional study was conducted on 225 patients admitted to
medical wards of Tikur Anbessa Specialized Hospital, Addis Ababa from March to June 2014. Data
regarding patient characteristics, medications, diagnosis, length of hospitalization, investigation,
and laboratory results were collected using data abstraction forms through review of patients’
medical card and medication charts. Identified DRPs were recorded and classified using DRP
registration forms. The possible intervention measures for the identified DRPs were proposed
and communicated to either the physician or the patient. Data were entered into Epi Info
7 and analyzed using SPSS version 21 (IBM Corp. Released 2012, Armonk, NY: IBM Corp).
Findings: DRPs were found in 52% of study subjects. A drug‑drug interaction (48% of all DRPs)
was the most common DRP followed by adverse drug reaction (23%). Anti‑infectives and
gastrointestinal medicines were commonly involved in DRPs. Drugs with the highest drug
risk ratio were gentamycin, warfarin, nifedipine, and cimetidine. The number of drugs taken
by the patient per day is an important risk factor for DRPs.
Conclusion: DRPs are common among medical ward patients. Polypharmacy has a significant
association with the occurrence of DRP. Drugs such as gentamycin, warfarin, nifedipine, and
cimetidine have the highest probability of causing DRP. So, patients who are taking either
of these drugs or polypharmacy should be closely assessed for identification and timely
correction of DRPs.
